Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders
نویسندگان
چکیده
منابع مشابه
Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders
Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclero...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0044099